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KMID : 0816120000030010063
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2000 Volume.3 No. 1 p.63 ~ p.67
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Diagnostic Utility of Tc-99m DISIDA Hepatobiliary Scintigraphy in the Diagnosis of Biliary Atresia
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Lee Byeong-Seon
Kim Jae-Seung
Choi Bo-Hwa
Kim Kyung-Mo
Moon Dae-Hyuk
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Abstract
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Purpose : Biliary atresia, one of the major causes of neonatal cholestais, is an
idiopathic, serious disorder, affecting the newborn that results in complete obstruction of
biliary tract. Successful reestablishment of bile flow is dependent on early surgical
intervention, early diagnosis is imperative. The authors evaluate the utility of
Tc-99m-labeled diisoprpyliminodiacetic acid (DISIDA) hepatobiliary scintigraphy in the
diagnosis of biliary atresia.
Methods : From January, 1995 to August, 1999, total 60 patients with neonatal
cholestasis underwent Tc-99m DISIDA hepatobiliary scintigraphy at Asan Medical
Center.
Results : The undelying causes of neonatal cholestasis were biliary atresia in 14,
neonatal hepatitis in 33, intrahepatic bile duct paucity in 9, and total parenteral nutrition
induced cholestasis in 4. All patient with biliary atresia were interpreted correctely in
DISIDA hepatobiliary scintigraphy, showing 100% sensitivity. Of the 46 patients with
neonatal hepatitis and other causes, 37 patients had intestinal radioactivity showing 80%
specificity.
Conclusion : Visualization of DISIDA in the intestinal tract indicates patency of the
biliary ducts and excludes the diagnosis of biliary atresia. But the absence of intestinal
excretion on the DISIDA hepatobiliary scintigraphy dose not necessarily indicate biliary
atresia.
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KEYWORD
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Biliary atresia, Neonatal cholestasis, Tc-99m DISIDA hepatobiliary scintigraphy,
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